In 2013, a research team from the Institute of Scientific Instruments of the Czech Academy of Sciences in Brno, led by Pavel Jurak, conducted the first ultra‑high‑frequency ECG (UHF‑ECG) experiments in collaboration with Pavel Leinveber and his group at St. Anne’s University Hospital, Brno. The team analyzed ECG signals with a 2 kHz bandwidth sampled at 5 kHz, revealing clinically relevant high‑frequency components up to 1.5 kHz. Software for computing high‑fidelity signal envelopes was developed, laying the foundation for further exploration of UHF‑ECG dynamics.

Subsequent clinical studies focused on monitoring ventricular asynchrony, waveform morphology, and amplitude variations across leads. Over the years, signal‑processing algorithms were refined, culminating in 2D time‑frequency averaging within the 150–1000 Hz band, introduced in 2019. Collaboration expanded to University Hospital Kralovské Vinohrady, Prague, under Karol Curila, leading to an EU structural grant supporting the design of the VDI Monitor — a hardware‑software system capable of detecting and analyzing clear UHF‑ECG signals.

The first VDI UHF‑ECG monitor was completed in 2019 and used in multiple clinical studies conducted by the founding institutions. These studies were successfully published and well-received in the scientific community.

Commercial development began in 2021, when Nilus Medical LLC designed the VDIAQ ECG signal amplifier, tested for mechanical, electrical, and EMC safety in 2022. The investigational system was used under IRB approval in more than 30 research centers across Great Britain, the Netherlands, the Czech Republic, Spain, Italy, South Africa, Bulgaria, and Hungary. The VDI Vision software was developed and validated using a database of over 10,000 recorded cases.

Under the leadership of Miroslav Navratil, appointed CEO in April 2022, VDI Technologies was founded by a group of individual founders and original research institutions. Convertible loan financing was provided by Cardion, a Brno‑based company that later became the lead investor in the first financing round.

In 2024, VDI Technologies obtained ISO 13485 certification. The VDI UHF‑ECG system, officially recognized as a CE‑certified medical device in 2025, marks its entry into clinical medicine.